The Grammy Award-winning trio will play Target Center in Minneapolis Dec. 5.
Tickets go on sale Sept. 20, and prices are yet to be announced.
The group last played Target Center in March 2012.
Since their 2008 debut album and Country Music Association Award for Best New Artist, the group has earned seven Grammy Awards and scored seven No. 1 hits on the country radio charts.
Lady Antebellum's stop in December comes on the first leg of its "Take Me Downtown Tour."
Last year the group toured 11 countries to more than 1 million fans, the Star Tribune says.
USA Today says the group will kick off its current tour Nov. 8 in Southaven, Miss.
The closest tour stops to the Twin Cities are in Fargo, N.D., Nov. 19, and Rapid City, S.D., Nov. 21.