The production -- which is being staged in celebration of 200th anniversary of author Jane Austen's classic novel -- runs through Aug. 31.
Kartheiser, who stars in the hit AMC series "Mad Men," first played the Guthrie in 1986, when at age 7 he played Tiny Tim in “A Christmas Carol.”
The actor also played small roles in the Guthrie’s 1990 productions of “Henry V” and “Henry IV," and also is an alum of the Children's Theatre Company in Minneapolis.
Kartheiser plays Mr. Darcy in "Pride and Prejudice," which also marks the first major role on the world stage for University of Minnesota grad Ashley Rose Montondo.
Montondo, a 2011 graduate of the University of Minnesota/Guthrie Theater BFA Actor Training Program, stars as Elizabeth Bennet opposite Kartheiser.
Local reviews of "Pride and Prejudice" are forthcoming.
Continuing its run at the Children's Theater Company this week is “If You Give a Mouse a Cookie,” a stage adaptation of Laura Joffe Numeroff’s best-selling children’s book.
Pioneer Press contributing critic Renee Valois says the show is appealing for both children and adults.
“Director Peter C. Brosius keeps the pace mostly manic, as befits a show aimed at very young children,” Valois writes. “There’s no time for anyone to get bored.”
“If You Give a Mouse a Cookie” plays through July 21.
Also continuing this week is the Guthrie Theater’s latest production, “Clybourne Park” at the venue’s McGuire Proscenium stage in Minneapolis.
“Clybourne Park” — which in 2012 earned playwright Bruce Norris a Pulitzer Prize and Tony Award for Best Play — is a satiric comedy that deals with race and class in response to Lorraine Hansberry’s “A Raisin in the Sun.”
Beginning in 1959, “Clybourne Park” follows a black family as they move into a white neighborhood in Chicago — and in the second act takes us to the same house in 2009 as gentrification sets in and the roles are reversed.
Chris Hewitt calls the play an “exemplary production” in his review for the Pioneer Press.
Hewitt also likens “Clybourne Park” to an orchestra performance, saying it it’s “a work of art where the ‘conductor,’ director Lisa Peterson, and the players are so united in their efforts that we hardly notice the dozens of talents who contributed to the production.”
The play runs through Aug. 4.