The plunging temperatures, which could see wind chills in the mid-60s below zero by Wednesday morning, has forced the closure of stores, cancelations of public meetings, and even the shutdown of the postal service.
The U.S. Postal Service has announced it's suspending deliveries on Wednesday due to "deteriorating weather conditions related to Polar Vortex Jayden."
This will include Minnesota, Iowa, western Wisconsin, western Illinois, the Dakotas, eastern Montana and parts of Nebraska, Missouri and Kansas.
In Minnesota, the cold is "life-threatening," with temps expected to bottom out in the Twin Cities at around 53 below wind chill at around 6 a.m. Wednesday.
Elsewhere, the cold is causing closures at grocery stores, including the Wedge Lyndale, Linden Hills and Seward Co-op stores.
Lunds & Byerlys and Kowalski's Markets meanwhile will have reduced hours on Wednesday, shutting its doors at 7 p.m.
The food service departments at several Hy-Vee supermarkets will close earlier, and its Market Grille restaurants will open later on Wednesday morning.
Other businesses affected include the Surly Brewing Destination Brewery in Northeast Minneapolis, which says it'll re-open at 11 a.m. on Thursday.
The Bell Museum, the Minnesota History Center, the Mill City Museum, and James J. Hill House will also be closed on Wednesday, same with the Excelsior Ice Castles attraction.
Most schools in the state will stay closed on Wednesday, with decisions expected to be taken during the day as to whether to re-open on Thursday.
Courthouses and city council meetings across the state have fallen victim to the weather, as indeed has the Minnesota Senate, which has canceled all hearings on Wednesday.
KARE 11 has a list of all the businesses it knows are closing on Wednesday, which you can find here.