Here's what people – everyone from Castile's girlfriend to President Barack Obama – have had to say about the incident.
Diamond Reynolds, the woman who filmed the aftermath of the shooting and broadcasted it live on Facebook, spoke at a news conference outside of the Governor's Residence Thursday, demanding justice and peace in the wake of her boyfriend's death.
St. Anthony Police Department
A desk clerk at the St. Anthony Police State on Silver Lake Road told BringMeTheNews Thursday that no one from the department would be commenting on the shooting, adding: "The investigation is being handled by the [Minnesota Bureau of Criminal Apprehension], so any statements will come from them."
The Bureau of Criminal Apprehension
The Minnesota Bureau of Criminal Apprehension says it is "conducting a thorough and independent investigation" into the fatal shooting.
The agency will interview witnesses and the officers involved, collect and analyze evidence (including video), and then give its findings to the county attorney for review.
The BCA says it will "provide additional details about the incident once the initial interviews are complete."
The US Department of Justice
President Barack Obama released a statement Thursday, saying it's "clear" fatal officer-involved shootings are "not isolated incidents."
He called them "symptomatic of the broader challenges within our criminal justice system, the racial disparities that appear across the system year after year, and the resulting lack of trust that exists between law enforcement and too many of the communities they serve."
Presidential candidate Hillary Clinton tweeted a statement regarding the shooting:
Gov. Mark Dayton and Lt. Gov. Tina Smith released statements Thursday, extending their condolences to Castile's family. Dayton also said he spoke to White House Chief of Staff Denis McDonough to request the U.S. Department of Justice "begin an immediate independent federal investigation into this matter."
He also spoke outside of the Governor's Residence during a news conference organized by community leaders. Watch it below.
Dayton is expected to answer questions from reporters at 3 p.m. Thursday.
US Sen. Franken
U.S. Sen. Al Franken said Thursday he is "horrified and heartbroken" about the shooting, adding Castile's family and friends deserve "nothing less than a full and independent investigation ... by the Department of Justice."
US Rep. McCollum
U.S. Rep. Betty McCollum, a Democrat who represents Falcon Heights and Minnesota's Fourth District, called for an "immediate investigation led by the U.S. Department of Justice."
She also called for respectful protests – both from activists and from police. Read her full statement here.
Sens. Hayden and Champion
Minnesota state Sens. Bobby Joe Champion, DFL-Minneapolis, and Jeff Hayden, DFL-Minneapolis, released a joint statement Thursday, demanding the U.S. Department of Justice investigates the incident.
Clarence Castile, Philando Castile's uncle, also spoke at the news conference Thursday, asking for the officer involved in the shooting to "tell the truth."
Teamsters Local 320
The organization, which Philando Castile was a part of, released a statement Thursday, said he will be "deeply missed."