Santana held the Rangers to two runs on three hits in 6.1 innings. He also struck out five.
This embed is invalid
With Texas leading 2-0 heading into the bottom of the seventh the Twins pulled even on a two-run home run from Trevor Plouffe. He finished the night 3-for-4 with the home run and both Twins' RBIs.
The game stayed tied until the 10th, when Ian Desmond hit a solo shot off Fernando Abad, giving the Rangers the lead for good.
Tyler Duffey (3-6) takes the mound for the Twins on Saturday afternoon against Texas' Chi Chi Gonzalez.