A fourth quarter collapse turned into an overtime loss, 94-86 in Chicago on Sunday.
It's the Lynx's second straight loss at the heels of a 10-game winning streak.
The Lynx (17-5) couldn't handle the 1-2 punch of Chicago's Elena Delle Donne and Sylvia Fowles. Delle Donne scored game-high 32 points and Fowles scored 31.
Minnesota led by 12 in the second half, but a late three-pointer by Delle Donne forced overtime, where the Sky outscored Minnesota, 15-7.
Seimone Augustus led the Lynx with 26 points. Maya Moore added 19 while Lindsay Whalen and Rebekkah Brunson finished with 16 and 14 points, respectively.