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The Twins opened their National League West Coast road trip with a 5-3 victory in San Diego on Tuesday night.
Kevin Correia went six innings and gave up three runs to pick up the victory. He started the game with four perfect innings, but San Diego got to him in the fifth as they strung together three runs on four hits to steal the lead at 3-2.
Minnesota rallied back, though. A wild pitch allowed Plouffe to score to even the score at 3 in the sixth.
Correia came back out and kept the Padres scoreless in the bottom of the sixth and his teammates put him in position to win the game when Josmil Pinto hit a sacrifice fly to score Eduardo Escobar with the go-ahead run.
The bullpen took over from there and Glenn Perkins picked up his 13th save with a 1-2-3 ninth inning.
The Twins and Padres continue their series on Wednesday night. Phil Hughes is on the mound for Minnesota against San Diego's Tyson Ross. First pitch is scheduled for 8:10.