It was close after two period from the Xcel Energy Center, but the Wild burned the Flames in the third, scoring three times to seal a 5-1 victory Tuesday.
Minnesota was led by three-point nights from Zach Parise and Mikko Koivu, and 10 skaters logged points for the Wild.
Josh Harding was once again fantastic in net, stopping 24 Calgary shots to pick up his eighth win in 11 games this season.
The Wild welcomed back forward Charlie Coyle who sat out Sunday's win after tweaking his knee Friday in his return from a knee injury that cost him nearly a month of the season. Coyle assisted on Minnesota's first goal off the stick of Koivu, while coming out of the night as a plus-one.
The Wild travel east to face Alex Ovechkin and the Washington Capitals Thursday at 6 p.m.