The Timberwolves held another late lead, but a career night for the Indiana center let the game slip away.
Anthony Edwards scored a career-high 28 points, but it wasn't enough to defeat the defending champs.
Kawhi Leonard and Lou Williams helped L.A. pull away in the second half.
The Wolves came back from a 23-point deficit but couldn't complete the comeback.
The Timberwolves bench scored 44 points, but Cleveland walked away with a 100-98 victory.
The Timberwolves star returned in an overtime loss to the Spurs.
As the Wizards star sat out, Washington handed the Timberwolves their third straight loss.
Minnesota opens the season at Brooklyn Wednesday night.
Reid was impressive for the Wolves during the Summer League.
Naz Reid is dominating in the Las Vegas Summer League.