The pair were last seen Monday afternoon.
An incident over the weekend spurred the sheriff to issue a release.
The 16-year-old driver and 14-year-old passenger survived the crash.
Sheriff's deputies say 40-50 people were at the party.
After the besties each suffered a chronic illness, they wanted to support others going through the same thing.
Teen births in Hennepin County dropped by two-thirds in a decade.
For the first time ever, the American Academy of Pediatrics offers recommendations on body modification.